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Sanofi to Acquire Blueprint Medicines in $9.5 Billion Deal to Boost Immunology Portfolio

by Team Lumida
June 2, 2025
in News
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Sanofi to Acquire Blueprint Medicines in $9.5 Billion Deal to Boost Immunology Portfolio
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Key Takeaways:

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  • Sanofi has agreed to acquire U.S.-based Blueprint Medicines for up to $9.5 billion, paying $129 per share in cash at closing.
  • The deal includes Blueprint’s approved drug for systemic mastocytosis, marketed as Ayvakit/Ayvakyt in the U.S. and EU, and its early-stage immunology pipeline.
  • Blueprint shareholders will also receive contingent value rights (CVRs) for milestone payments of $2 and $4, tied to regulatory and development achievements.
  • The acquisition strengthens Sanofi’s immunology portfolio, focusing on rare immunological diseases.

What Happened?

Sanofi, the French pharmaceutical giant, announced its acquisition of Blueprint Medicines, a U.S. biotech company specializing in rare immunological diseases, for up to $9.5 billion. The deal includes an upfront payment of $129 per share in cash and contingent milestone payments of up to $6 per share.

Blueprint’s portfolio includes Ayvakit/Ayvakyt, a drug approved in the U.S. and EU for systemic mastocytosis, a rare immunological disease. The acquisition also provides Sanofi access to Blueprint’s early-stage immunology pipeline, further bolstering its position in the immunology space.

Blueprint’s shares closed at $101.35 on Friday, making the $129 per share offer a significant premium.


Why It Matters?

The acquisition aligns with Sanofi’s strategy to expand its immunology portfolio and strengthen its position in treating rare diseases. Ayvakit/Ayvakyt, a key asset in the deal, addresses a niche but critical market, offering Sanofi a competitive edge in the immunology sector.

For Blueprint Medicines, the deal provides the financial backing and global reach of Sanofi to accelerate the development and commercialization of its pipeline.

The transaction also reflects the broader trend of large pharmaceutical companies acquiring biotech firms to diversify their portfolios and address unmet medical needs in specialized areas like rare diseases.


What’s Next?

The deal is subject to regulatory approvals and is expected to close later this year. Sanofi will focus on integrating Blueprint’s assets into its existing immunology operations while advancing the development of Blueprint’s early-stage pipeline.

Investors will monitor the achievement of the contingent milestones tied to the $2 and $4 CVR payments, as well as the broader impact of the acquisition on Sanofi’s financial performance and market position.

The acquisition could also spark further consolidation in the biotech sector, as large pharmaceutical companies continue to seek growth opportunities in specialized therapeutic areas.

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© 2025 Lumida Wealth Management LLC is an SEC registered investment adviser. Privacy Policy. Cookies Policy.
Disclaimer Important Information This site is for informational purposes only. Information presented on this site does not constitute as investment advice.

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Lumida's website (referred to herein as the "Website") is limited to the dissemination of general information pertaining to its advisory services, together with access to additional investment-related information, publications, and links. Accordingly, the publication of the Website on the Internet should not be construed by any client and/or prospective client Lumida’s solicitation to effect, or attempt to effect transactions in securities, or the rendering of personalized investment advice for compensation, over the Internet.

Any subsequent, direct communication by Lumida with a prospective client will be conducted by a representative that is either registered or qualifies for an exemption or exclusion from registration in the state where the prospective client resides.

‍Lead Capture Forms: By submitting your contact information in the forms on this site, you are not obligated to invest in Lumida's product or services.
‍Address: Lumida Wealth Management, 25 W 39th Street Suite 700, New York, NY 10018